Molecular landscape analysis of azinothricin-type natural products enables the identification of kettapeptin from <i>Streptomyces durmitorensis</i>.

ABSTRACT: The azinothricin family of hybrid hexadepsipeptide-polyketide natural products exhibit remarkable bioactivities, including potent antibacterial, antitumor, antimalarial and anti-inflammatory activities. However, only a few azinothricin-type natural products are currently known, and the biosynthetic potential of microbes remains underexplored. In this work, 137 candidate biosynthetic gene clusters (BGCs) were identified using a genome-mining strategy based on cblaster homology screening. Furthermore, Streptomyces durmitorensis DSM 41863 was prioritized for in-depth experiment due to its unique PKS module expansion, leading to the discovery of kettapeptin, the azinothricin-type metabolite isolated from this species for the first time. Additionally, a putative biosynthetic pathway for

SUBMITTER: Chen H 

PROVIDER: S-EPMC12804128 | biostudies-literature | 2026 Jun

REPOSITORIES: biostudies-literature