Gut microbiota-derived propionic acid mitigates age-related albumen quality deterioration by modulating magnum functions.

ABSTRACT: The declined albumen quality during the late laying phase is associated with age-related magnum dysfunction, in which to the roles of gut microbiota is unclear. This study aimed to elucidate the relationship between gut microbiota and magnum function, and its impact on albumen quality. Hy-Line Brown layers at peak (30 wk) and late (70 wk) laying phases were compared to assess age-related changes in albumen quality, magnum function, and gut microbiota. Fecal microbiota transplantation (FMT) from peak- to late-phase hens was conducted to assess functional effects. Microbiome and metabolome analyses were then integrated to identify key bacterial taxa and metabolites. The role of the leading candidate metabolite was further validated through dietary supplementation. Results showed that late-ph

SUBMITTER: Chen J 

PROVIDER: S-EPMC12804134 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature