Associations of LDL and HDL cholesterol with lung function decline and risk of airflow obstruction in a community-based cohort.

ABSTRACT: Dyslipidemia may affect pulmonary function through systemic inflammation and metabolic pathways; however, longitudinal evidence remains limited. This study examined the associations of baseline low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol levels with subsequent rates of lung function decline and the incidence of airflow obstruction in a community-based observational cohort, Korean Genome and Epidemiology Study (KoGES). We analyzed 7381 participants without baseline airflow obstruction. LDL cholesterol was categorized as ≤ 130 mg/dL (LDL_low), 130-160 mg/dL (LDL_medium), and > 160 mg/dL (LDL_high), while HDL cholesterol was classified as ≤ 50 mg/dL (HDLlow) and > 50 mg/dL (HDL_high). Annual changes in FEV₁ and FVC were

SUBMITTER: Yoo J 

PROVIDER: S-EPMC12804180 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature