Determinants of survival after re-resection for recurrent glioblastoma: a meta-analysis.

ABSTRACT:

Purpose

Glioblastoma (GBM) inevitably recurs despite maximal safe resection and standard chemoradiotherapy. The factors influencing survival after first recurrence and re-resection remain controversial.

Research question

What are the prognostic factors influencing survival following re-resection of glioblastoma?

Methods

A systematic search of major databases was conducted for original studies reporting on survival outcomes. Data on hazard ratios (HR) for overall survival and key prognostic factors were extracted, followed by meta-analyses of univariate and multivariate Cox models. Study quality and risk of bias were assessed.

Results

A total of 30 studies were included. Gross total resection and methylated MGMT promoter status were significantly associated with

SUBMITTER: Baby MV 

PROVIDER: S-EPMC12804209 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature