[Aerosol therapy in spontaneously breathing tracheostomized patients: an in vitro study].

ABSTRACT:

Background

Aerosol therapy is widely used in tracheostomized patients, particularly during prolonged weaning, to improve mucociliary clearance and manage bronchoconstriction; however, there is a lack of standardized guidelines to optimize nebulization therapy in this patient population. Different nebulizer types and interfaces can affect the efficiency of drug deposition, thereby affecting the therapeutic efficacy. Understanding these differences is essential to improve aerosol delivery strategies in clinical practice.

Objective

This in vitro study aimed to evaluate the drug deposition rates of different aerosol generators and interfaces to determine the most effective combination for spontaneously breathing tracheostomized patients. Specifically, we compared the performance

SUBMITTER: Kropp Y 

PROVIDER: S-EPMC12804279 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature