Subcutaneous and visceral adipose tissue lipidome in children reveals novel lipid species involved in obesity.

ABSTRACT: Overweight impacts over 390 million children and adolescents worldwide, of whom around 160 million are living with obesity. Adipose tissue biology in pediatric obesity is still relatively unknown. Adaptations to obesity including fat mobilization and remodeling are being investigated. The objective was to examine the lipidomic profile of subcutaneous and visceral adipose tissue (sWAT and vWAT, respectively) in children with obesity compared to those with normal weight, in order to identify novel lipid species modulated by obesity. Thirty pediatric patients with and without obesity were prospectively recruited at a referral single center and clinical data were reported. sWAT and vWAT samples were obtained for lipidomic analysis. Novel lipid species, including ether-linked triglycerides, eth

SUBMITTER: Soria-Gondek A 

PROVIDER: S-EPMC12804287 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature