Electrical gastrodin-polyurethane spiral conduits with micro/nano-structure for accelerating peripheral nerve regeneration.

ABSTRACT: Peripheral nerve injuries tend to cause the proximal nerve unable to contact the corresponding target organ, resulting in sensory and motor dysfunction. The simple filling materials within nerve conduits are often inadequate for axonal ingrowth and directional regeneration. In this study, to enhance the guidance effect and achieve physiologically adaptive function, a 3D nanofibrous polyurethane (PU) scaffold with oriented microchannels was engineered using electrospinning and manual curling techniques. The electrospun fibrous membranes can be manually curled up into tubular structures with spiral and longitudinal multi-channels. The immunoregulatory and conductive properties were developed by being grafted gastrodin and aniline trimer (AT, 2.6 % and 5 %). Gastrodin stimulated proliferation

SUBMITTER: Lan X 

PROVIDER: S-EPMC12804388 | biostudies-literature | 2026 May

REPOSITORIES: biostudies-literature