Pulsed Radiofrequency Analgesia Alters EEG Spatiotemporal Dynamics: A Microstate-Based Exploratory Study.

ABSTRACT:

Introduction

Pulsed radiofrequency (PRF) is a well-established neuromodulation technique widely used for managing neuropathic pain. Lumbosacral radicular pain, a common neuropathic condition, is often refractory to conventional treatments. Although dorsal root ganglion (DRG) PRF has emerged as a promising intervention, its therapeutic efficacy is often limited and variable, likely due to an incomplete understanding of its mechanisms. To elucidate the neural mechanisms underlying DRG PRF analgesia, this study characterized treatment-induced alterations in microstate spatiotemporal dynamics and examined their correlation with pain intensity, thereby assessing their potential as neurophysiological markers.

Methods

We recorded high-density electroencephalograms (EEG) in healthy

SUBMITTER: Yang Y 

PROVIDER: S-EPMC12804541 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature