Effect of Esketamine Combined with Lidocaine on Opioid Requirements in the Elderly Undergoing Laparoscopic Colorectal Cancer Surgery: A Randomized, Double-Blind, Controlled Trial.

ABSTRACT:

Introduction

Postoperative pain after surgery for colorectal cancer (CRC) is prone to multiple complications, and opioids are accompanied by significant side effects. There is still unclear evidence regarding the combination of esketamine and lidocaine. This trial was designed to get into the bottom of the synergistic effect of esketamine and lidocaine on reducing opioid requirements in the elderly undergoing CRC surgery.

Methods

This study enrolled 151 patients to establish the control group (group C, n = 50), the esketamine group (group S, n = 50), and the esketamine + lidocaine group (group SL, n = 51). The primary endpoint was the total sufentanil consumption within 24 h post-surgery.

Results

During the first 24 h postoperatively, compared with group C {103.22 μg

SUBMITTER: Xie JX 

PROVIDER: S-EPMC12804563 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature