Real-World Comparative Outcomes of Dual vs. Single Antiplatelet Therapy in Acute Ischemic Stroke: A Retrospective Cohort Analysis.

ABSTRACT:

Introduction

Short-term use of dual antiplatelet therapy (DAPT) is superior to single antiplatelet therapy (SAPT) for early outcomes in acute ischemic stroke (AIS). However, the long-term effects of SAPT and DAPT remain unclear. This study aimed to evaluate long-term effects of DAPT and SAPT on clinical outcomes in patients with AIS.

Methods

A retrospective cohort study was conducted at three tertiary hospitals in Saudi Arabia, including 912 patients with AIS who received either DAPT (aspirin plus clopidogrel) or SAPT (aspirin or clopidogrel alone). The primary outcome was the incidence of net adverse clinical and cerebral events (NACCEs), which was defined as the incidence of any hemorrhagic transformation within 30 days, or stroke recurrence and/or all-cause mortality with

SUBMITTER: Alatawi Y 

PROVIDER: S-EPMC12804589 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature