A novel migrasome-associated lncRNA model for clear cell renal cell carcinoma prognosis and immune response prediction.

ABSTRACT: The most common kind of kidney cancer, clear cell renal cell carcinoma (ccRCC), presents challenges in clinical management and prognosis. Although the roles of long non-coding RNAs (lncRNAs) and migrasomes in tumorigenesis and tumor development have gradually attracted attention, there is currently relatively little research on migrasomes in ccRCC. The objective of this research was to construct a migrasome-associated lncRNAs model and assess its predictive value for immune reactions and survival outcomes in patients with ccRCC. First, the Cancer Genome Atlas (TCGA) database was utilized to acquire transcriptome data and clinical information pertaining to ccRCC. Using this data, Pearson correlation identified migrasome-associated lncRNAs, and Cox regression analysis was utilized to build a

SUBMITTER: Zhang L 

PROVIDER: S-EPMC12804687 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature