Alternating magnetic fields enhance anti-biofilm activity across pathogen and antibiotic space.

ABSTRACT: Prosthetic joint infection (PJI) is a severe complication of total joint arthroplasty, contributing to significant patient morbidity and increased healthcare costs. The formation of biofilm on the implant hinders effective therapy, and removal of the prosthesis is frequently required. High frequency alternating magnetic fields (AMF) have emerged as a promising noninvasive approach to disrupt biofilm and have the potential to augment antibiotic activity. This study evaluated the impact of AMF on antibiotic activity in biofilms of clinically relevant PJI pathogens. Across multiple bacterial strains, AMF significantly improved biofilm eradication when administered with antibiotics, achieving greater reductions in bacterial burden compared to antibiotic monotherapy. There was an average reduct

SUBMITTER: Hairgrove M 

PROVIDER: S-EPMC12804712 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature