Exploring stationary phase morphologies as pathways to greener and faster LC for analyzing sofosbuvir and ledipasvir.

ABSTRACT: Green chemistry has a beneficial influence on the environment and the pharmaceutical enterprises' economy. Research and quality control laboratories worldwide conduct millions of analyses daily, employing liquid chromatography as the primary analytical technique. Furthermore, advancements in stationary phase technologies aimed at achieving faster and more efficient separations have introduced a new objective for chromatographers. This objective is to supersede conventional methodologies that rely heavily on substantial quantities of organic solvents, pose environmental hazards and incur considerable economic costs. The aim of this work is to provide a brief comparison between monolithic, core-shell and traditional fully porous stationary phases. This could help analysts by offering options

SUBMITTER: Ibrahim AE 

PROVIDER: S-EPMC12804721 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature