Periplaneta americana glycoprotein alleviates fatigue through modulation of oxidative stress and gut microbiota.

ABSTRACT: Fatigue is an increasingly prominent global health issue. Periplaneta americana glycoprotein (PAG) possesses multiple pharmacological activities including antioxidation, regulation of gut microbiota (GM) and immunity, which are highly consistent with the targets of anti-fatigue treatment. This study aimed to investigate the efficacy and mechanisms of PAG in anti-fatigue. Initially, the antioxidant activity of PAG was evaluated in vitro. Subsequently, a fatigue mouse model was established to evaluate its anti-fatigue effects in vivo. Finally, Spearman correlation analysis was conducted to explore correlations between gut microbiota shifts, short-chain fatty acid (SCFA) production, and fatigue indicators. The results showed that PAG possesses significant antioxidant activity. Furthermore, PA

SUBMITTER: Chen Z 

PROVIDER: S-EPMC12804747 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature