Multimodal neuroimaging reveals brain neurochemical disturbances associated with superoxide dismutase in first-episode drug-naive schizophrenia.

ABSTRACT: Reduced antioxidant defense observed in first-episode drug-naïve schizophrenia (SCZ) may contribute to impaired cognition of SCZ. However, the underlying relationships among antioxidant stress-neuroimaging-cognition pathway and neurotransmitter dysfunction remain unclear. In this study, 75 patients with first-episode drug-naïve SCZ and 85 age and sex matched healthy controls underwent clinical evaluation and brain MRI. Two brain imaging measurements, including gray matter volume (GMV) from structural MRI (sMRI) and fractional amplitude of low frequency fluctuations (fALFF) from resting-state functional MRI, were jointly analyzed with a data-driven multivariate fusion method. Serum superoxide dismutase (SOD) levels was used as a reference to guide fusion of two MRI features. To investigate

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC12804751 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature