Porous tantalum cage loaded with CGF promotes interbody fusion in a rat XLIF model.

ABSTRACT: This study addresses the clinical challenge of nonunion in spinal interbody fusion by developing a novel composite implant: a porous tantalum (PTa) cage loaded with concentrated growth factors (CGF). The CGF-PTa cage synergistically combines the mechanical strength and osteoconductivity of chemically vapor-deposited PTa with the sustained release of angiogenic (VEGF) and osteogenic (TGF-β and IGF-1) factors from CGF. Using a rat extreme lateral interbody fusion (XLIF) model, the research systematically evaluates the efficacy of this composite in promoting bone regeneration and spinal fusion. Results from radiography, micro-CT, biomechanical testing, histological staining, and immunohistochemistry consistently show that CGF-PTa significantly enhances bone ingrowth, fusion rate, and mechanic

SUBMITTER: Wu H 

PROVIDER: S-EPMC12804753 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature