Reduced IGF-1 signaling fails to limit Alzheimer's disease progression in a novel rat model of IGF-1R haploinsufficiency.

ABSTRACT: The growth hormone/insulin-like growth factor-1 (GH/IGF-1) signaling pathway has been strongly implicated in the aging process. Lifespan is profoundly increased in both male and female dwarf mice, while low IGF-1 signaling per se leads to more modest improvements in female lifespan. However, as opposed to the consistency offered by studies in dwarf mice, nuances in the relationship of this axis with health and disease have also been observed, including in rat models of low GH/IGF-1 signaling. This complexity further extends to cognitive decline and Alzheimer's disease (AD), where this relationship has proven to be nuanced. To help address these gap, we have generated a new rat model of Igf1r^+/- haploinsufficiency, to assess effects on metabolic health and AD. Similar to mice, we

SUBMITTER: Narayan S 

PROVIDER: S-EPMC12804757 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature