Hyaluronic acid-chitosan conjugated PLGA nanoparticles for dual chemo-photothermal therapy of triple-negative breast cancer.

ABSTRACT: Triple-negative breast cancer (TNBC) lacks effective treatment choices, resulting in poor prognosis and systemic toxicity caused by traditional chemotherapy. To present a bi-functional nanoplatform that combines hyaluronic acid (HA) with chitosan (CS)-conjugated poly (lactic-co-glycolic acid) (PLGA) nanoparticles loaded with doxorubicin (DOX) and indocyanine green (ICG) as co-cargo to achieve synergistic chemo-photothermal therapy (CPTT). HA-CS-PLGA nano-particles were produced through the use of solvent evaporation through a technique known as double-emulsion and conjugation using EDC/NHS. Their physicochemical characteristics, their ability to respond to pH and release, and their ability to work as photothermal were described. Cellular uptake, cytotoxicity, apoptosis, and reactive oxygen

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC12804827 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature