Dopamine and serotonin neurotransmissions exert complementary control over primate approach and avoidance.

ABSTRACT: Efficient selection of appropriate responses to emotionally valenced stimuli is crucial for adaptive behavior, and disruptions in such approach-avoidance processes are common in various psychopathological disorders. While the dopamine and serotonin systems are primary targets for psychiatric medications, their precise roles in approach-avoidance behaviors remain unclear. To address this, we compared the effects of acute administration of methylphenidate (MPH) and fluoxetine, which respectively block dopamine and serotonin transporters (DAT and SERT), in four monkeys trained to perform an approach-avoidance task involving responses to valenced stimuli. We conducted PET scans to assess and localize drug binding levels at behaviorally effective doses. The two pharmacological agents improved t

SUBMITTER: Gauthier L 

PROVIDER: S-EPMC12804911 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature