Unveiling the anti-inflammatory activity of chloroform fraction of curcuma wallichii and its phytoconstituents by in vivo and in silico studies.

ABSTRACT: Curcuma genus has been widely used in folk medicine for its diverse medicinal properties. This study explored the in vitro and in vivo anti-inflammatory activity of the chloroform fraction of Curcuma wallichii (CFCW) and assessed the drug-likeness of identified compounds using computational tools. Phytochemical screening, gas chromatography-mass spectrometry (GC-MS), and high-performance liquid chromatography (HPLC) analyses of the CFCW confirmed the presence of different bioactive compounds. The in vitro methods include the human red blood cell (HRBC) membrane stabilization and egg albumin denaturation assays, where the fraction exhibited substantial anti-inflammatory activity in a dose-dependent manner. In vivo evaluation using the formalin-induced licking test and acetic acid-induced wr

SUBMITTER: Hossain MS 

PROVIDER: S-EPMC12804923 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature