CBX2 promoted oral squamous cell carcinoma via increasing CEP55/NF-κB/METTL3/SHP2 signaling induced metastasis/proliferation and angiogenesis.

ABSTRACT: To investigate the mechanism by which CBX2 promotes oral squamous cell carcinoma (OSCC) by increasing CEP55/NF-κB/METTL3/SHP2 signaling, leading to metastasis, proliferation, and angiogenesis. We employed a comprehensive research approach. Through bioinformatics analysis (GSE153918 dataset), we identified differentially expressed genes (DEGs) and enriched pathways associated with OSCC and CBX2. Immunohistochemistry (IHC) was used to detect CBX2 expression in both tumor and peritumoral tissues from OSCC patients. Twenty-four BALB/c nude mice were divided into three groups and infected with or without CBX2-KD and/or METTL3-OE lentiviruses. Tumor volume and weight changes were observed in nude mice. IHC was performed to observe the protein expression of CBX2 and METTL3. The oral squamous cell

SUBMITTER: Ma S 

PROVIDER: S-EPMC12804991 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature