Using multimodal cortical parcellations to identify novel regions of the human cerebral cortex associated with cognitive performance.

ABSTRACT: Cognitive performance has been found to be associated with the complex structure of human cerebral cortex. However, due to the limitations of previous cortical parcellation atlases, the cortical genetic patterns determining cognitive performance remain unknown. Here, we utilized the latest Human Connectome Project Multi-Modal Parcellation (HCP-MMP) atlas to divide the cerebral cortex into 180 regions per hemisphere. We investigated the shared genetic architecture between four types of magnetic resonance imaging (MRI)-derived cortical phenotypes and cognitive performance using large-scale genome-wide association studies (N for cortical phenotypes = 36,843; N for cognitive performance = 257,828). We observed extensive genetic overlap between cortical surface area, volume, and local gyrificat

SUBMITTER: Qiu S 

PROVIDER: S-EPMC12805006 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature