Safety and Effectiveness of Long-Term Isoniazid Treatment for the Prevention of Tuberculosis in High-Risk Dialysis Patients.

ABSTRACT:

Introduction

Patients with chronic kidney disease (CKD) receiving dialysis (CKD-5D) are at increased risk for tuberculosis (TB), which significantly heightens the risk of mortality. Long-term isoniazid prevention therapy (IPT) to prevent TB is a promising strategy, although the safety and effectiveness of the approach in this high-risk population is unknown.

Methods

Between 2019 and 2025, universal long-term IPT was administered to patients with CKD-5D (N = 182) receiving dialysis in Gqeberha, South Africa (post-IPT cohort), an area with high TB rates. The incidence of TB post-IPT was compared with a historical CKD-5D cohort (pre-IPT) from the same unit (n = 111). Primary outcomes included incident TB and adverse events attributable to IPT.

Results

The i

SUBMITTER: Freercks R 

PROVIDER: S-EPMC12805011 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature