Injectable living hydrogel as engineered biotherapeutic to promote tooth-extraction wound healing and alveolar bone regeneration.

ABSTRACT: Effective wound healing and functional bone regeneration following tooth extraction remain clinical challenges, underscoring the significant need for multifunctional strategies that address the complex, multistage and translational demands of socket management. Herein, an injectable live biotherapeutic hydrogel was fabricated by integrating probiotic Lactobacillus rhamnosus GG (LGG) and calcium phosphate nanoparticles (CP NPs) into a photopolymerizable poly (ethylene glycol) (PEG) matrix. Upon in situ injection and activation with dental blue light, the hydrogel rapidly forms a conformal, protective and bioactive scaffold to the extraction socket. Therapeutically, LGG probiotics remodel the wound microenvironment through antibacterial and immunomodulatory bioactivities to promote ea

SUBMITTER: Guo J 

PROVIDER: S-EPMC12805084 | biostudies-literature | 2026 May

REPOSITORIES: biostudies-literature