Differences in mortality by donor sex and age in heart transplantation: An individual patient data meta-analysis.

ABSTRACT:

Background

Prior studies suggested a recipient sex-dependent association between donor sex and heart transplant survival. We hypothesized that donor age also modifies the association between donor sex and recipient mortality.

Methods

Deceased donor heart transplant recipients (1988-2019, n = 109,432) recorded in the Scientific Registry of Transplant Recipients (SRTR) and the Collaborative Transplant Study (CTS) were analyzed. We used multivariable Cox regression models to estimate the association between donor sex and mortality, accounting for the modifying effects of recipient sex and donor age. Results from cohort-specific models were combined using individual patient data meta-analysis.

Results

Among female recipients, mortality was lower with female than ma

SUBMITTER: Sugianto RI 

PROVIDER: S-EPMC12805093 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature