Spatially Resolved Proteomic Mapping in Skin Organoid for Hair Follicle Development.

ABSTRACT: Hair follicle development is a complex, highly regulated process involving interactions between epithelial and mesenchymal cells. However, the specific molecular mechanisms and important biological processes of hair follicle development remain poorly understood. How the extracellular matrix is involved in the hair follicle formation from hair germs remains to be investigated. In this study, we applied spatially resolved proteomic mapping to investigate the process of hair follicle development in skin organoids at different stages: D55, D75, D90, D140, D150, and D170, which corresponds to that from hair germ formation to hair follicle aging. Our analysis identified dynamic changes in protein expression and active protein synthesis during hair follicle appearance. We observed stage-specific

SUBMITTER: Liang L 

PROVIDER: S-EPMC12805098 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature