B3GNT8-mediated glycosylation maintains intestinal homeostasis and protects against colitis.

ABSTRACT: Emerging evidence suggests that alterations in intestinal epithelial glycosylation are implicated in the pathogenesis of inflammatory bowel disease (IBD). However, the intricate roles of gut glycosylation in maintaining intestinal homeostasis remain inadequately elucidated. Beta 1, 3-N-acetylglucosaminyltransferases (B3GNTs) are Golgi glycosyltransferases involved in the biosynthesis of poly-N-acetyl-lactosamine chains. In this study, we here create B3gnt8 knockout (B3gnt8^-/-) mice to investigate its precise effects on intestinal homeostasis. Our findings reveal that both messenger RNA (mRNA) and protein levels of B3GNT8 are significantly diminished in the inflamed mucosa of pediatric IBD patients. Furthermore, the levels of B3GNT8 were negatively correlated with ulcerative coli

SUBMITTER: Mao H 

PROVIDER: S-EPMC12805103 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature