Characterisation of the gut-lung axis microbiome in clinically stable patients with chronic obstructive pulmonary disease.

ABSTRACT:

Background

Airway and gut dysbiosis have been reported in Chronic Obstructive Pulmonary Disease (COPD); however, their relationship and association with clinical features remain poorly understood. We aimed to characterise the lung and gut microbiome in patients with stable COPD and controls.

Methods

Prospective, multicentre, longitudinal and controlled study of n = 60 stable patients with COPD and n = 30 controls. In them, we analysed 16S rRNA-seq in oropharyngeal (OP) swabs, sputum, bronchoalveolar lavage fluid (BALF) and stool. Weighted gene co-expression network analysis (WGCNA) was employed in each sample type to identify modules of co-abundant bacteria associated with clinical traits.

Findings

We found that the microbiome in airway and stool samples was highly di

SUBMITTER: Viglino J 

PROVIDER: S-EPMC12805107 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature