Percutaneous Coronary Intervention or Medical Therapy for Chronic Total Occlusion in Older Adults.

ABSTRACT:

Background

Managing coronary chronic total occlusion (CTO) in older adults remains challenging due to a scarcity of evidence.

Objectives

We aimed to assess the association of attempted/successful CTO percutaneous coronary intervention (CTO-PCI) with quality of life (QoL) measures, all-cause mortality, and cardiovascular outcomes in studies that adequately represented older adults.

Methods

A systematic search of 6 databases was performed to identify randomized trials and observational studies comparing CTO-PCI with optimal medical therapy (OMT) in adults, with particular inclusion of studies adequately representing older individuals. Meta-regression analyses were conducted to estimate relative risks (RRs) for key outcomes.

Results

A total 29 studies encompassing

SUBMITTER: Jamil Y 

PROVIDER: S-EPMC12805175 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature