Improved Survival in Octogenarians With Heart Failure: 15-Year Cohort Study From a National Referral Center.

ABSTRACT:

Background

Octogenarians (aged ≥80 years) represent a significant subpopulation of heart failure (HF) patients yet remain underrepresented in clinical trials.

Objectives

This study evaluates trends in mortality among octogenarians with HF between 2009 and 2024.

Methods

This was a retrospective analysis of HF patients treated at a single tertiary center. The primary outcome was all-cause mortality. Kaplan-Meier survival analysis and Cox proportional hazards regression models were applied, stratifying patients by age (octogenarians or older and nonoctogenarians), by time period (before and after June 2016), HF type (heart failure with preserved [HFpEF] and reduced ejection fraction), and frailty status.

Results

Among 32,892 patients (median age 72 years, IQR: 64-

SUBMITTER: Copeland V 

PROVIDER: S-EPMC12805179 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature