Ondansetron reduces seizures and improves cognitive impairment in a rat model of temporal lobe epilepsy.

ABSTRACT: Temporal lobe epilepsy (TLE) remains an intractable chronic neurological disorder. Emerging evidence suggests a crucial modulatory role for the 5-hydroxytryptamine 3 receptor (5-HT₃R) in epilepsy. Ondansetron, a selective 5-HT₃ receptor antagonist widely used as an antiemetic, has demonstrated neuroprotective effects in preclinical models of several neurological disorders. However, its potential therapeutic efficacy in chronic TLE has not yet been investigated. In this study, we evaluated ondansetron's effects on spontaneous recurrent seizures (SRS), cognitive function, and hippocampal neurodegeneration in a pilocarpine-induced rat model of chronic TLE. Rats received three weeks of intraperitoneal ondansetron, after which spontaneous recurrent seizures (SRS), cognitive performan

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12805289 | biostudies-literature | 2026 Jun

REPOSITORIES: biostudies-literature