Supramolecular helicity dependent osteogenesis and angiogenesis crosstalk of periodontal ligament stem cell.

ABSTRACT: The two pillars supporting effective tissue regeneration are multipotent stem cells and matrix materials that direct differentiation. The chirality of the extracellular matrix is a key structural characteristic that affects stem cell fate. However, little is known about the effects of either molecular chirality or supramolecular helicity on the differentiation of periodontal ligament stem cells (PDLSCs), a safe and easily accessible stem cell source. Here, we constructed fibrils through the co-assembly of chiral amino acid derivative enantiomers (l/d-GC18) and a bridging pyrazine molecule. The helicity of the fibrils depends on both the molecular chirality of the amino acid and the stoichiometric ratio of the two components. Our results showed that molecular chirality and sup

SUBMITTER: Deng Z 

PROVIDER: S-EPMC12805306 | biostudies-literature | 2026 May

REPOSITORIES: biostudies-literature