Brain-peripheral proteome crosstalk in Alzheimer's disease with and without diabetes mellitus.

ABSTRACT:

Background

Although considerable research has investigated diabetes mellitus (DM) as a risk factor for Alzheimer's disease (AD) dementia, the mechanistic understanding of the associations between peripheral and central biological processes in AD and AD within DM remains limited.

Methods

We performed tandem mass tag-based phosphoproteome profiling on postmortem prefrontal cortex (n = 191), deltoid muscle (n = 191), and antemortem serum (n = 96) from older adults with/without pathologic AD and with/without DM (DM/NDM).

Results

We observed significant brain-muscle and brain-serum correlations in phosphorylated and unphosphorylated peptides. Among individuals with DM, 59 were with AD and 36 were without. Among NDM, 63 were with AD and 33 were without. In a differential ex

SUBMITTER: Yaskolka Meir A 

PROVIDER: S-EPMC12805325 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature