Design, synthesis, <i>in silico</i> studies, and antiproliferative activity of a novel series of thiazole/1,2,3-triazole hybrids as apoptosis inducers and multi-kinase inhibitors endowed with anti-breast cancer activity.

ABSTRACT: A novel series of thiazole/1,2,3-triazole hybrids has been developed and evaluated for their in vitro anticancer efficacy. Compounds 10c, 10e, 10k, 10m, 10n, and 10o exhibited superior anticancer efficacy against the evaluated cancer cell lines, demonstrating a favorable safety profile, particularly against MCF-7 breast cancer, compared to erlotinib. The in vitro anti-breast cancer assay of compounds 10e and 10k demonstrated potent antiproliferative activity against the MCF-7 breast cancer cell line, with IC₅₀ values of 24 nM and 21 nM, respectively, relative to the reference erlotinib, which exhibited an IC₅₀ value of 40 nM. To elucidate their antiproliferative mechanism, tests for EGFR, HER-2, VEGFR-2, and BRAF^V600E kinases were performed. C

SUBMITTER: Mohamed FAM 

PROVIDER: S-EPMC12805330 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature