Functional precision approach in patients with very high risk acute lymphoblastic leukaemia in India: a single-centre cohort study.

ABSTRACT:

Background

Persistence of measurable residual disease (MRD) and high-risk cytogenetics are established predictors of relapse in childhood acute lymphoblastic leukaemia (ALL).

Methods

Outcomes of children with ALL treated with the ICiCLe-ALL-2014 protocol at a single centre, between August 2013 and May 2023 were analysed. Co-culture ex-vivo drug response profiling (DRP) was performed on diagnostic or relapsed samples. Patients classified as very high risk (VHR) received DRP guided therapeutic modifications. Event free (EFS) and overall (OS) survival were compared across risk categories.

Findings

Among 715 patients, at a median 55 (50-58) months, the 3-year EFS for standard-risk, intermediate-risk, high-risk B, T-ALL and VHR were 71% (64%-78%), 67% (58%-75%), 77%

SUBMITTER: Sidhu J 

PROVIDER: S-EPMC12805335 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature