Irradiated tumor volume as a predictor of local recurrence and radionecrosis in lung cancer with brain metastases treated with stereotactic radiosurgery.

ABSTRACT:

Background

Stereotactic radiosurgery (SRS) is a standard treatment of brain metastases (BM), but it may lead to radionecrosis (RN) or local recurrence (LR). This study evaluates irradiated tumor volume as a predictor of LR and RN in SRS-treated lung cancer patients with BM.

Methods

We retrospectively analyzed 431 lung cancer patients with BM who underwent SRS at Karolinska University Hospital (all-comers, 2009-2020). Associations among irradiated tumor volume and risks of RN, symptomatic RN, and LR at 6 and 12 months were assessed using Cox regression models. Furthermore, we evaluated the diagnostic performance of methionine positron emission tomography-computed tomography (PET-CT) in differentiating RN from LR.

Results

Forty patients (9.3%) developed asymptomatic RN,

SUBMITTER: Koulouris A 

PROVIDER: S-EPMC12805339 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature