Joint tissue plasticity in hemophilia: insights from the Joint Activity and Damage Exam ultrasound protocol.

ABSTRACT:

Background

Progressive arthropathy is a debilitating condition that affects hemophilic joints as a consequence of hemarthroses. However, our understanding of the trajectory of potentially destructive processes at the tissue level remains limited and requires longitudinal imaging studies.

Objectives

To longitudinally characterize ultrasonographic joint tissue changes in adults with hemophilia using the Joint Activity and Damage Exam (JADE) protocol, and to examine their relationships with joint health status, hemarthrosis, and serum biomarkers of tissue turnover.

Methods

We prospectively studied adults with hemophilia (A or B) of any severity and associated arthropathy at 3 North American sites. We assessed joint health using the Hemophilia Joint Health Score (HJHS) an

SUBMITTER: Sheth P 

PROVIDER: S-EPMC12805341 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature