COVID-19 immunopathological features for the prediction and prevention of future emerging respiratory viral infections.

ABSTRACT:

Background & objective

Emerging viral infections can initiate a global pandemic with high mortality. Understanding the immunopathogenesis of these viruses is critical to developing effective strategies for managing/preventing such outbreaks.

Methods

Transcriptomics analysis was performed in a UAE cohort with respective COVID-19 severities. The findings were correlated with published studies of COVID-19 severity/progression GWAS, and transcriptomics data of patients infected with different respiratory viruses.

Results

The transcriptional profiling distinguished significantly between the infected COVID-19 groups and identified the interferon-induced protein, GBP2, as a common significantly up-regulated gene among the different COVID-19 infection severities (nomin

SUBMITTER: Bouzid A 

PROVIDER: S-EPMC12805346 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature