Coiled-coil register transitions and coupling with the effector's inhibitory site enables high fold changes in blue light-regulated diguanylate cyclases.

ABSTRACT: Cellular signaling cascades rely on transfer of information from one protein to another or within a single protein. To facilitate signal integration, specific structural motifs evolved that allow signal processing and also enable modular downstream response integration, facilitating sophisticated regulatory mechanisms. On a structural level, especially coiled-coil helices are frequently observed as signaling motifs. In diguanylate cyclases (DGCs) featuring GGDEF domains, N-terminal coiled-coils frequently activate systems by rearrangements of the interdimer active site. The variety of sensory domains that modulate this structural equilibrium in response to different stimuli highlights the importance of DGCs in bacterial adaptation. One interesting example of sensor DGCs is blue light-activ

SUBMITTER: Vide U 

PROVIDER: S-EPMC12805367 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature