Ligand assisted Co(ii) catalyzed direct C-H alkylation of aryl ketones with diverse alkyl halides.

ABSTRACT: A new cobalt(ii) catalyst, [Co(η¹-fluorenyl)-(µ₂-OH)(MeOH)₂]₂, enables the direct ortho-C-H alkylation of aryl ketones with stoichiometric quantities of primary, secondary, and tertiary alkyl halides at room temperature using commercial-grade methanol. It proceeds efficiently without the need for excess alkyl halide, Grignard reagent, or transient directing imine groups. It exhibits remarkable functional-group tolerance and exceptional air- and moisture-stability. Furthermore, the protocol enables the alkylation of strained and functional group-bearing alkyl halides with high chemoselectivity. Notable advantages of this catalyst are its economic viability, scalability, and recyclability, which set it apart from other organometallic catalys

SUBMITTER: Nigade A 

PROVIDER: S-EPMC12805386 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature