Inhibition, But Not Depletion, of Erk Signaling Ameliorates Anthracycline-Induced Cardiotoxicity in Zebrafish.

ABSTRACT:

Background

Anthracycline-induced cardiotoxicity (AIC) is a unique type of cardiomyopathy that limits the clinical use of anthracyclines in cancer therapy. Although several cardiomyopathy-related pathways have been identified, including extracellular signal-regulated kinase (ERK) signaling, pathway-specific interventions for AIC remain unclear.

Objectives

The aim of this study was to investigate the role of Erk signaling in AIC using zebrafish genetics.

Methods

A zebrafish model of AIC was used to screen genes in known cardiomyopathy pathways, including Erk signaling. Heterozygous and homozygous mutants were evaluated for their modifying effects on AIC. In parallel, pharmacologic studies with ERK inhibitors were conducted to assess dose-dependent therapeutic effects of

SUBMITTER: Moossavi M 

PROVIDER: S-EPMC12805405 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature