Factors associated with discordant visual and quantitative amyloid PET results.

ABSTRACT:

Introduction

Factors underlying discordant visual and quantitative amyloid beta-positron emission tomography (Aβ-PET) results and their clinical implications are not well understood.

Methods

Participants from the 1Florida Alzheimer's Disease Research Center (1FLADRC) underwent Aβ-PET, blood draw, brain magnetic resonance imaging (MRI), and neuropsychological testing. We evaluated differences in demographics, apolipoprotein E (APOE) status, biomarkers, and cognition among older adults with concordant and discordant visual-quantitative Aβ-PET. Discordance was defined as positive visual read (V) of Aβ-PET with below-threshold Centiloid quantification (Q; CL <25; V+/Q-) or negative visual read with CL ≥25 (V-/Q+).

Results

We studied 386 participants (mean age ± SD:

SUBMITTER: Guevara JE 

PROVIDER: S-EPMC12805418 | biostudies-literature | 2026 Jan-Mar

REPOSITORIES: biostudies-literature