CHA-driven SERS-nanoenzyme sensor for ultra-sensitive diagnosis of gastric precancerous lesions.

ABSTRACT: Early identification and timely intervention of precancerous lesions of gastric cancer are the core strategies to block their malignant transformation into gastric cancer (GC). This study developed a dual functional sensor that combined surface-enhanced Raman scattering (SERS) activity and nanoenzyme catalytic properties. The sensor was driven by catalytic hairpin self-assembly (CHA) technology triggered by the target microRNA-21 (miR-21), promoting the conversion of 3,3',5,5'-tetramethylbenzidine (TMB) and signal amplification of TMB oxidation (ox-TMB). This work used Au-platinum nanoparticles (Au-Pt NPs) as nanozyme probes and silica-encapsulated ferrite (Fe₃O₄@SiO₂) as capture probes. In the presence of target miR-21, CHA technology induced Au-Pt NPs to

SUBMITTER: Huang Y 

PROVIDER: S-EPMC12805419 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature