The Gwangju Alzheimer's & Related Dementias (GARD) cohort: Over a decade of Asia's largest longitudinal multimodal study.

ABSTRACT:

Introduction

Alzheimer's disease (AD) is a major public health concern in Korea, with a high prevalence among older adults. A community-based longitudinal study is essential for tracking disease progression, identifying biomarkers, and developing targeted prevention and treatment strategies. The Gwangju Alzheimer's & Related Dementias (GARD) cohort was established to address these needs through a multimodal approach.

Methods

Participants aged ≥60 years undergo comprehensive clinical evaluations, neuroimaging, and biospecimen collection for multi-omics analyses (genomics, transcriptomics, proteomics, and metagenomics) at baseline and systematic follow-up visits.

Results

From over 17,000 screened individuals, 12,877 were enrolled. Baseline diagnoses include 5,123 cognit

SUBMITTER: Choi KY 

PROVIDER: S-EPMC12805525 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature