American ginseng (<i>Panax quinquefolius</i> L.) extracts (G1899) reverse stress-induced behavioral abnormalities in mice.

ABSTRACT:

Background

Stress affects brain functions, which leads to the development of mental disorders. There is increasing focus on the role of nutritional, herbal and nutraceutical compounds on mental and cognitive functioning. Interestingly, studies suggest that American ginseng (Panax quinquefolius L.) extracts (G1899) improve cognition.

Methods

We examined whether G1899 showed protective effects on stress-induced behavioral changes in animals. 200 mg/kg G1899 was orally administered daily for 4 weeks to 2-3-month-old female and male mice before inducing stress. To induce acute stress in animals, we intraperitoneally injected a low dose of lipopolysaccharides (LPS) (10 μg/kg), and saline was used as a control. We also used chronic restraint stress (CRS) as a chronic stress

SUBMITTER: Lee R 

PROVIDER: S-EPMC12805544 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature