HLA-F: A Non-Classical Gene With Growing Interest.

ABSTRACT: The HLA-F is a non-classical HLA class I gene that belongs to the class Ib major histocompatibility complex (MHC) molecules. It is distinguished in the literature from its classical MHC class Ia counterparts by a minor frequency of polymorphisms. The exact function of HLA-F remains unknown, but recent publications emphasise the essential immunological role of this gene in infectious diseases, cancer research, organ transplantation and autoimmune diseases. The rapidly evolving sequencing techniques within the last years allow the accession of larger genomic regions at reasonable costs. In this regard we developed a long-range PCR assay, covering the entire HLA-F gene, including the flanking untranslated regions (UTRs). According to the positions of the 5' and 3' amplification primers, the P

SUBMITTER: Grunen N 

PROVIDER: S-EPMC12805605 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature