Therapeutic potential of saponins for allergic rhinitis: Molecular mechanisms and clinical perspectives (Review).

ABSTRACT: Allergic rhinitis (AR) is a chronic inflammatory disorder of the nasal mucosa, often a comorbid condition with asthma, posing notable challenges for treatment. Current therapies, including corticosteroids and antihistamines, primarily target nasal symptoms but exhibit limited efficacy against concurrent asthma and systemic inflammation. Saponins, a class of bioactive plant‑derived compounds, have garnered attention for their pleiotropic effects, including immunomodulation, anti‑inflammatory activity and antioxidant properties. Saponins, such as ginsenosides, notoginsenosides, astragalosides, saikosaponins and platycodins, modulate key molecular pathways in AR, including T helper 1/2 cell balance, mast cell stabilization and NF‑κB signaling. Their multi‑target action and low toxicity profil

SUBMITTER: Liang BY 

PROVIDER: S-EPMC12805626 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature