Estrogen regulation in the prostate underlies racial disparity in men with benign prostatic hyperplasia.

ABSTRACT: Lower urinary tract symptoms (LUTS), associated with benign prostatic hyperplasia (BPH), are an aging-related disease, with more than 210 million cases worldwide. Estrogen exposure and estrogen regulation have been implicated in a variety of disease processes, with estrogen receptor (ER)-α pathways associated with disease progression and ERβ pathways considered to be disease-protective through enhanced apoptosis and reduced cellular proliferation. Preclinical models of LUTS/BPH have shown that ERα activation contributes to disease initiation and progression. Self-identified African American (AA) men have a high incidence of LUTS/BPH, with increased incidence of non-surgical treatment failure, larger prostates at time of surgery, and surgery occurring at a younger age compared with self-ide

SUBMITTER: Liu TT 

PROVIDER: S-EPMC12805628 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature