Metabolic and lipid alterations in multiple sclerosis linked to disease severity.

ABSTRACT:

Background

The circulating metabolome incorporates multiple levels of biological interactions and is an emerging field for biomarker discovery. However, few studies have linked metabolite levels with quantitative neurologic function assessments in people with multiple sclerosis (pwMS).

Objectives

We quantified metabolomic differences between pwMS and healthy controls (HCs) and assessed the association of metabolites with disease severity.

Methods

We profiled 517 metabolites using liquid chromatography-mass spectrometry (Biocrates Inc.) for participants from the MS Partners Advancing Technology and Health Solutions (MS PATHS). We conducted a multicenter cross-sectional study and applied linear regression to assess the association between metabolites and neurological fu

SUBMITTER: Noroozi R 

PROVIDER: S-EPMC12805657 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature