Plasma volume status in type 2 diabetes and its association with antidiabetic therapy.

ABSTRACT:

Background

Plasma Volume Status (PVS), an index that quantifies the deviation of an individual's plasma volume from the expected volume, plays an important role in cardiovascular homeostasis. Although PVS expansion is well recognized in conditions like heart failure and chronic kidney disease, its relationship with type 2 diabetes (T2D) and antidiabetic treatment remains uncertain.

Methods

We conducted an observational study comparing PVS in adults with T2D and healthy controls matched for sex, age, and BMI. In a separate analysis of a larger T2D cohort, we investigated the association between PVS and different antidiabetic therapies. PVS was calculated using established formulas incorporating hematocrit, body weight, and sex.

Results

PVS was significantly expanded in

SUBMITTER: Cutruzzola A 

PROVIDER: S-EPMC12805681 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature